Role of ADP receptors on platelets in the growth of ovarian cancer

Author:

Cho Min Soon1ORCID,Noh Kyunghee2,Haemmerle Monika3,Li Dan4,Park Hyun3ORCID,Hu Qianghua1,Hisamatsu Takeshi3,Mitamura Takashi3,Mak Sze Ling Celia3,Kunapuli Satya5,Ma Qing4,Sood Anil K.367,Afshar-Kharghan Vahid1ORCID

Affiliation:

1. Department of Benign Hematology, University of Texas MD Anderson Cancer Center, Houston, TX;

2. Gene Therapy Research Unit, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea;

3. Department of Gynecologic Oncology and Reproductive Medicine and

4. Department of Stem Cell Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX;

5. Department of Physiology, Temple University Medical School, Philadelphia, PA; and

6. Department of Cancer Biology and

7. Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points P2Y12 is important in the interaction between platelets and cancer cells. A P2Y12 inhibitor or P2Y12 deficiency reduces tumor growth in murine models of ovarian cancer.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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