CMV serostatus still has an important prognostic impact in de novo acute leukemia patients after allogeneic stem cell transplantation: a report from the Acute Leukemia Working Party of EBMT

Author:

Schmidt-Hieber Martin12,Labopin Myriam3456,Beelen Dietrich78,Volin Liisa9,Ehninger Gerhard10,Finke Jürgen11,Socié Gerard12,Schwerdtfeger Rainer13,Kröger Nicolaus14,Ganser Arnold15,Niederwieser Dietger16,Polge Emmanuelle4,Blau Igor W.2,Mohty Mohamad345617

Affiliation:

1. HELIOS Clinic Berlin Buch, Clinic for Hematology, Oncology and Tumorimmunology, Berlin, Germany;

2. Charité University School of Medicine, Clinic for Hematology and Oncology, Berlin, Germany;

3. Clinical Hematology and Cellular Therapy Department,

4. European Group for Blood and Marrow Transplantation Acute Leukemia Working Party Office, Assistance Publique-Hôpitaux de Paris, Hospital Saint Antoine, Paris, France;

5. University Pierre et Marie Curie, Paris, France;

6. Institut national de la santé et de la recherche médicale Unité Mixte de Recherche en Santé 938, Paris, France;

7. University Hospital Essen, Department of Bone Marrow Transplantation, Essen, Germany;

8. Deutsches Register für Stammzelltransplantationen (DRST) Study Office, Ulm, Germany;

9. Helsinki University Central Hospital, Hematology Department, Helsinki, Finland;

10. University Hospital Dresden, Clinic for Hematology and Oncology, Dresden, Germany;

11. University Hospital Freiburg, Clinic for Hematology and Oncology, Freiburg, Germany;

12. Hospital St. Louis, Paris, France;

13. German Clinic for Diagnostics, Wiesbaden, Germany;

14. University Medical Center Hamburg-Eppendorf, Hematology Department, Hamburg, Germany;

15. Hannover Medical School, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover, Germany;

16. University Hospital Leipzig, Clinic for Hematology and Oncology, Leipzig, Germany; and

17. University of Nantes, Hematology Department, Nantes, France

Abstract

Key Points Donor and/or recipient CMV seropositivity is still associated with an adverse prognosis in de novo acute leukemia patients after allo-SCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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