Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies-Reference-Cited by-同舟云学术

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Published:2013-12-05 Issue:24 Volume:122 Page:3892-3898
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Manwani Deepa¹,Frenette Paul S.²³⁴

Affiliation:

1. Departments of Pediatrics,

2. Medicine, and

3. Cell Biology, and

4. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY

Abstract

Abstract Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin–reactivating agent hydroxyurea are currently the mainstay of treatment. Discoveries over the past 2 decades have highlighted the important contributions of various cellular and soluble participants in the vaso-occlusive cascade. The role of these elements and the opportunities for therapeutic intervention are summarized in this review.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/24/3892/1370308/3892.pdf

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