Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload

Author:

Aydinok Yesim1,Kattamis Antonis2,Cappellini M. Domenica3,El-Beshlawy Amal4,Origa Raffaella5,Elalfy Mohsen6,Kilinç Yurdanur7,Perrotta Silverio8,Karakas Zeynep9,Viprakasit Vip10,Habr Dany11,Constantinovici Niculae12,Shen Junwu11,Porter John B.13

Affiliation:

1. Department of Pediatric Hematology, Ege University Hospital, Izmir, Turkey;

2. First Department of Pediatrics, University of Athens, Athens, Greece;

3. Universitá di Milano, Ca Granda Foundation Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy;

4. Department of Hematology, Pediatric Hospital, Cairo University, Cairo, Egypt;

5. Ospedale Regionale per le Microcitemie, University of Cagliari, Cagliari, Italy;

6. Thalassemia Center, Children's Hospital, Ain Shams University, Cairo, Egypt;

7. Medical Facility, Cukurova University, Adana, Turkey;

8. Department of Woman, Child and of General and Specialist Surgery, I°Policlinico II°Università di Napoli, Naples, Italy;

9. Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey;

10. Department of Pediatrics and Thalassemia Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand;

11. Novartis Pharmaceuticals, East Hanover, NJ;

12. Novartis Pharma AG, Basel, Switzerland; and

13. Department of Hematology, UCL Cancer Institute, University College London, London, United Kingdom

Abstract

Key Points DFX-DFO combination followed by DFX monotherapy led to a meaningful decrease in myocardial and liver iron in severe siderosis patients. Substantial liver iron reduction may be helpful in patients needing rapid control of liver iron (eg, pretransplant or planned pregnancy).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference35 articles.

1. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major.;Kirk;Circulation,2009

2. International survey of T2* cardiovascular magnetic resonance in β-thalassemia major.;Carpenter;Haematologica,2013

3. Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction.;Chouliaras;Br J Haematol,2010

4. Thalassaemia International Federation Guidelines for the Clinical Management of Thalassaemia, 2nd Revised Edition. 2008. Available at: www.thalassaemia.org.cy/wp-content/uploads/pdf/educational-programmes/Publications/Guidelines%20%282008%29/Thalassaemia%20Guidelines%20ENGLISH.pdf. Accessed May 11, 2015

5. Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia.;Pennell;Blood,2010

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