A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders-Reference-Cited by-同舟云学术

A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders

Published:2014-12-11 Issue:25 Volume:124 Page:3768-3771
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Velusamy Thirunavukkarasu¹,Kiel Mark J.¹,Sahasrabuddhe Anagh A.¹,Rolland Delphine¹,Dixon Catherine A.¹,Bailey Nathanael G.¹,Betz Bryan L.¹,Brown Noah A.¹,Hristov Alexandra C.¹,Wilcox Ryan A.²,Miranda Roberto N.³,Medeiros L. Jeffrey³,Jeon Yoon K.⁴,Inamdar Kedar V.⁵,Lim Megan S.¹,Elenitoba-Johnson Kojo S. J.¹

Affiliation:

1. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI;

2. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI;

3. Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston TX;

4. Department of Pathology, Seoul National University Hospital, Seoul, South Korea; and

5. Department of Pathology, Henry Ford Health System, Detroit, MI

Abstract

Key Points Whole-transcriptome sequencing reveals NPM1-TYK2 gene fusion in cutaneous CD30-positve lymphoproliferative disorders. NPM1-TYK2 activates STAT signaling and is a therapeutic target in a subset of cutaneous CD30-positive lymphoproliferative disorders.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/25/3768/1465175/3768.pdf

Reference12 articles.

1. Chromosome translocations: dangerous liaisons revisited.;Rowley;Nat Rev Cancer,2001

2. The impact of translocations and gene fusions on cancer causation.;Mitelman;Nat Rev Cancer,2007

3. Role of ABL family kinases in cancer: from leukaemia to solid tumours.;Greuber;Nat Rev Cancer,2013

4. ChimeraScan: a tool for identifying chimeric transcription in sequencing data.;Iyer;Bioinformatics,2011

Cited by 85 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The 5th edition of the World Health Organization Classification of mature lymphoid and stromal tumors – an overview and update;Leukemia & Lymphoma;2024-01-08

2. Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH);Current Research in Translational Medicine;2023-10

3. Updates in pathobiological aspects of anaplastic large cell lymphoma;Frontiers in Oncology;2023-09-22

4. Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment;Frontiers in Oncology;2023-09-07

5. Primary Cutaneous Anaplastic Large Cell Lymphoma—A Review of Clinical, Morphological, Immunohistochemical, and Molecular Features;Cancers;2023-08-14