The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm-Reference-Cited by-同舟云学术

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm

Published:2014-12-18 Issue:26 Volume:124 Page:3956-3963
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sangkhae Veena¹²,Etheridge S. Leah¹³,Kaushansky Kenneth¹,Hitchcock Ian S.¹²

Affiliation:

1. Department of Medicine, Stony Brook University, Stony Brook, NY;

2. Centre for Immunology and Infection, Department Biology, and

3. Department of Biology, University of York, Heslington Campus, York, United Kingdom

Abstract

Key Points MPL is essential for the development of JAK2V617F-positive myeloproliferative neoplasms in vivo. Ablation or reduction of Mpl significantly reduces the pool of neoplastic hematopoietic stem cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/26/3956/1466143/3956.pdf

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4. Thrombopoietin and the hematopoietic stem cell.;Kaushansky;Ann N Y Acad Sci,2005

5. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia.;Ihara;Proc Natl Acad Sci USA,1999

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