CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status-Reference-Cited by-同舟云学术

CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status

Published:2015-01-22 Issue:4 Volume:125 Page:731-739
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sellar Rob S.¹²,Vargas Frederick Arce¹,Henry Jake Y.¹,Verfuerth Stephanie³,Charrot Sarah²,Beaton Brendan³,Chakraverty Ronjon³,Quezada Sergio A.¹,Mackinnon Stephen³,Thomson Kirsty J.²,Peggs Karl S.¹²

Affiliation:

1. Department of Haematology, University College London Cancer Institute, London, United Kingdom;

2. Department of Haematology, University College London Hospital, London, United Kingdom; and

3. Department of Haematology, Royal Free Hospital, London, United Kingdom

Abstract

Key Points CMV serostatus significantly influences chimerism levels after T-cell–depleted allogeneic transplantation. CMV-specific T cells are exclusively of recipient origin after R+/D− T-cell–depleted transplants and appear to provide protective immunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/4/731/1387399/731.pdf

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