Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Author:

Iacovelli Stefano1,Hug Eva2,Bennardo Sara1,Duehren-von Minden Marcus2,Gobessi Stefania1,Rinaldi Andrea3,Suljagic Mirza1,Bilbao Daniel4,Bolasco Giulia4,Eckl-Dorna Julia5,Niederberger Verena5,Autore Francesco6,Sica Simona6,Laurenti Luca6,Wang Hongsheng7,Cornall Richard J.8,Clarke Stephen H.9,Croce Carlo M.10,Bertoni Francesco311,Jumaa Hassan212,Efremov Dimitar G.1

Affiliation:

1. Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Rome, Italy;

2. Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany;

3. Lymphoma and Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland;

4. European Molecular Biology Laboratory, Rome, Italy;

5. Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria;

6. Department of Hematology, Catholic University Hospital “A. Gemelli,” Rome, Italy;

7. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD;

8. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom;

9. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC;

10. The Ohio State University Comprehensive Cancer Center, Columbus, OH;

11. IOSI Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and

12. Institute of Immunology, University Clinics Ulm, Ulm, Germany

Abstract

Key Points Cell autonomous BCR interactions and interactions with low-affinity autoantigens drive leukemia development in an in vivo model of CLL. BCR signals induced by binding to external antigen can increase the aggressiveness of CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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