Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex-Reference-Cited by-同舟云学术

Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

Published:2015-01-15 Issue:3 Volume:125 Page:562-569
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Wei¹,Deng Wei²,Zhou Liang²,Xu Yan¹,Yang Wenjun³,Liang Xin²,Wang Yizhen¹,Kulman John D.⁴,Zhang X. Frank¹,Li Renhao²

Affiliation:

1. Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, PA;

2. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA;

3. Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX; and

4. Puget Sound Blood Center, Seattle, WA

Abstract

Key Points Pulling of VWF A1 domain that is engaged to GPIb-IX induces unfolding of a hitherto unidentified mechanosensitive domain in GPIbα. The spatial proximity of the mechanosensitive domain to GPIbβ and GPIX suggests a novel mechanism of platelet mechanosensing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/3/562/1344779/562.pdf

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