Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy-Reference-Cited by-同舟云学术

Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy

Published:2014-12-04 Issue:24 Volume:124 Page:3572-3576
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Van Gool Frédéric¹,Molofsky Ari B.²³,Morar Malika M.¹,Rosenzwajg Michelle⁴,Liang Hong-Erh⁵,Klatzmann David⁴,Locksley Richard M.²⁵⁶,Bluestone Jeffrey A.¹²

Affiliation:

1. Diabetes Center,

2. Department of Microbiology, Immunology, and Molecular Genetics, and

3. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA;

4. Assistance Publique – Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), Paris, France; and

5. Howard Hughes Medical Institute and

6. Department of Medicine, University of California, San Francisco, San Francisco, CA

Abstract

Key Points Tissue resident group 2 innate lymphoid cells are the main cells producing IL-5 and driving eosinophilia in response to low-dose IL-2 therapy. We described a novel cellular network activated during IL-2 treatment that may lead to a more efficient use of IL-2 in immunotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/24/3572/1382191/3572.pdf

Reference23 articles.

1. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.;Liao;Immunity,2013

2. The role of interleukin-2 during homeostasis and activation of the immune system.;Boyman;Nat Rev Immunol,2012

3. Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy.;Skrombolas;Expert Rev Clin Immunol,2014

4. Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer.;van Haelst Pisani;Blood,1991

5. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.;Tang;Immunity,2008

Cited by 95 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Low-dose interleukin-2 in birch pollen allergy: a phase-2 randomized double-blind placebo-controlled trial;2024-09-04

2. IL-2 based cancer immunotherapies: an evolving paradigm;Frontiers in Immunology;2024-07-24

3. IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity;Cancer Discovery;2024-04-09

4. The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial;Journal of Autoimmunity;2024-04

5. Interleukin‐2‐induced skin inflammation;European Journal of Immunology;2024-03-02