Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice-Reference-Cited by-同舟云学术

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

Published:2015-01-01 Issue:1 Volume:125 Page:162-174
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li-Harms XiuJie¹,Milasta Sandra²,Lynch John³,Wright Christopher¹,Joshi Aashish¹,Iyengar Rekha¹,Neale Geoffrey⁴,Wang Xi⁵,Wang Yong-Dong⁶,Prolla Tomas A.⁷,Thompson James E.⁸,Opferman Joseph T.⁵,Green Douglas R.²,Schuetz John³,Kundu Mondira¹

Affiliation:

1. Department of Pathology,

2. Department of Immunology,

3. Department of Pharmaceutical Sciences,

4. Hartwell Center for Bioinformatics & Biotechnology,

5. Department of Cell and Molecular Biology, and

6. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN;

7. Department of Genetics, University of Wisconsin-Madison, Madison, WI; and

8. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY

Abstract

Key Points Mitochondrial dysfunction in aged mtDNA-mutator mice is associated with activation of mechanistic target of rapamycin and suppression of autophagy in erythroid cells. Autophagy maintains mitochondrial function in erythroid progenitors of mtDNA-mutator mice, and disrupting it accelerates onset of anemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/1/162/1383185/162.pdf

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