Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

Author:

Cayrol Florencia1,Díaz Flaqué María Celeste1,Fernando Tharu2,Yang Shao Ning2,Sterle Helena Andrea1,Bolontrade Marcela3,Amorós Mariana3,Isse Blanca4,Farías Ricardo Norberto4,Ahn Haelee2,Tian Ye F.5,Tabbò Fabrizio6,Singh Ankur5,Inghirami Giorgio6,Cerchietti Leandro2,Cremaschi Graciela Alicia17

Affiliation:

1. Neuroimmunomodulation and Molecular Oncology Department, Institute for Biomedical Research (BIOMED), National Research Council of Argentina (CONICET), Catholic University of Argentina (UCA), Buenos Aires, Argentina;

2. Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY;

3. Laboratory of Molecular and Cellular Therapy, Foundation Institute Leloir-IIBBA, Buenos Aires, Argentina;

4. Department of Nutritional Biochemistry, CONICET, National University of Tucumán, and Institute of Biological Chemistry “Dr Bernabé Bloj,” San Miguel de Tucumán, Tucumán, Argentina;

5. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY;

6. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY; and

7. Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Abstract

Key Points We elucidate a molecular mechanism by which thyroid hormones sustain TCL survival. We demonstrate that the membrane receptor of THs, integrin αvβ3, constitutes a potential target for TCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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