Prognostic factors for remission of and survival in acquired hemophilia A (AHA): results from the GTH-AH 01/2010 study

Author:

Tiede Andreas1,Klamroth Robert2,Scharf Rüdiger E.3,Trappe Ralf U.45,Holstein Katharina6,Huth-Kühne Angela7,Gottstein Saskia2,Geisen Ulrich8,Schenk Joachim9,Scholz Ute10,Schilling Kristina11,Neumeister Peter12,Miesbach Wolfgang13,Manner Daniela14,Greil Richard15,von Auer Charis16,Krause Manuela17,Leimkühler Klaus18,Kalus Ulrich19,Blumtritt Jan-Malte1,Werwitzke Sonja1,Budde Eva20,Koch Armin20,Knöbl Paul21

Affiliation:

1. Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

2. Internal Medicine, Vivantes Clinic Friedrichshain, Berlin, Germany;

3. Hemostasis, Hemotherapy, and Transfusion Medicine, Heinrich Heine University Center, Düsseldorf, Germany;

4. Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany;

5. Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Evangelisches Diakonie-Krankenhaus Bremen, Bremen, Germany;

6. Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany;

7. Hemophilia Care Center, SRH Kurpfalzkrankenhaus Heidelberg, Heidelberg, Germany;

8. Institute for Clinical Chemistry and Laboratory Medicine, Freiburg University Hospital, Freiburg, Germany;

9. Clinical Hemostaseology and Transfusion Medicine, Saarland University Hospital, Homburg/Saar, Germany;

10. Center of Coagulation Disorders, Leipzig, Germany;

11. Hematology and Oncology, Jena University Hospital, Jena, Germany;

12. Hematology, Graz Medical University, Graz, Austria;

13. Hematology and Oncology, Johann Wolfgang Goethe University Hospital, Frankfurt/Main, Germany;

14. Clinical Chemistry, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany;

15. Hematology, Hemostasis, and Oncology, Paracelsus Medical University, Salzburg, Austria;

16. Hematology and Oncology, Mainz University Hospital, Mainz, Germany;

17. Internal Medicine, German Diagnostic Clinic, Wiesbaden, Germany;

18. Anesthesiology, Evangelical Hospital, Bielefeld, Germany;

19. Transfusion Medicine, Charité University Hospital, Berlin, Germany;

20. Biometry, Hannover Medical School, Hannover, Germany; and

21. Hematology and Hemostasis, Vienna Medical University, Vienna, Austria

Abstract

Key Points This study is the first to assess prognostic factors in patients with AHA treated according to a uniform immunosuppressive regimen. Residual factor VIII activity and inhibitor concentration at baseline are potentially useful predictors of remission.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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