Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts-Reference-Cited by-同舟云学术

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

Published:2007-08-01 Issue:3 Volume:110 Page:799-805
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Peterson Luke F.¹,Boyapati Anita¹,Ahn Eun-Young¹,Biggs Joseph R.¹,Okumura Akiko Joo¹,Lo Miao-Chia¹,Yan Ming¹,Zhang Dong-Er¹

Affiliation:

1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Abstract

Abstract Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/110/3/799/1292441/zh801507000799.pdf

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