Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation

Author:

Bredeson Christopher1,LeRademacher Jennifer2,Kato Kazunobu3,DiPersio John F.4,Agura Edward5,Devine Steven M.6,Appelbaum Frederick R.7,Tomblyn Marcie R.8,Laport Ginna G.9,Zhu Xiaochun2,McCarthy Philip L.10,Ho Vincent T.11,Cooke Kenneth R.12,Armstrong Elizabeth3,Smith Angela3,Rizzo J. Douglas2,Burkart Jeanne M.2,Pasquini Marcelo C.2

Affiliation:

1. The University of Ottawa at the Ottawa Hospital Research Institute, Ottawa, ON, Canada;

2. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

3. Otsuka Pharmaceutical Development and Commercialization, Inc, Princeton, NJ;

4. Siteman Cancer Center, Barnes Jewish Hospital, Washington University School of Medicine, St. Louis, MO;

5. Baylor University Medical Center, Dallas, TX;

6. James Cancer Center, The Ohio State University Medical Center, Columbus, OH;

7. Fred Hutchinson Cancer Research Center, Seattle, WA;

8. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

9. Division of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, CA;

10. Roswell Park Cancer Institute, Buffalo, NY;

11. Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA; and

12. Pediatric BMT Program, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD

Abstract

Key PointsCompared with TBI, IV-BU resulted in superior survival with no increased risk for relapse or TRM. The results support the use of myeloablative IV-BU vs TBI-based conditioning regimens for treatment of myeloid malignancies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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