Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo-Reference-Cited by-同舟云学术

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

Published:2013-12-12 Issue:25 Volume:122 Page:4094-4106
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ma Dongying¹,Mizurini Daniella M.²,Assumpção Teresa C. F.¹,Li Yuan¹,Qi Yanwei³,Kotsyfakis Michail⁴,Ribeiro José M. C.¹,Monteiro Robson Q.²,Francischetti Ivo M. B.¹

Affiliation:

1. Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

2. Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;

3. Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and

4. Institute of Parasitology, Biology Centre of the Academy of Sciences of Czech Republic, České Budějovice, Czech Republic

Abstract

Key Points Desmolaris, a major anticoagulant from vampire bat saliva, has been identified as a novel FXIa inhibitor. Desmolaris inhibits arterial thrombosis at concentrations that does not impair hemostasis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4094/1371645/4094.pdf

Reference50 articles.

1. Tissue factor pathway inhibitor and the revised theory of coagulation.;Broze;Annu Rev Med,1995

2. Mechanisms of thrombus formation.;Furie;N Engl J Med,2008

3. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis.;Roberts

4. In vivo roles of factor XII.;Renne;Blood,2012

5. Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes.;Colman;Blood,1997

Cited by 54 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutic Potential of FXI Inhibitors: Hype or Hope?;Drugs;2024-07-29

2. The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease;Journal of Thrombosis and Thrombolysis;2024-04-25

3. Factor XI: structure, function and therapeutic inhibition;Journal of Thrombosis and Thrombolysis;2024-04-16

4. Pharmacological and clinical appraisal of factor XI inhibitor drugs;European Heart Journal - Cardiovascular Pharmacotherapy;2024-01-09

5. Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants;Life;2023-04-11