Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies-Reference-Cited by-同舟云学术

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Published:2014-01-30 Issue:5 Volume:123 Page:678-686
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kohrt Holbrook E.¹,Thielens Ariane²,Marabelle Aurelien¹³,Sagiv-Barfi Idit¹,Sola Caroline²,Chanuc Fabien²,Fuseri Nicolas²,Bonnafous Cécile²,Czerwinski Debra¹,Rajapaksa Amanda¹,Waller Erin¹,Ugolini Sophie³,Vivier Eric⁴,Romagné François²,Levy Ronald¹,Bléry Mathieu²,André Pascale²

Affiliation:

1. Department of Medicine, Division of Oncology, Stanford University, Stanford, CA;

2. Innate Pharma, Marseille, France;

3. Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Université de Lyon, Lyon, France; and

4. Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Parc scientifique et technologique de Luminy, Marseille, France

Abstract

Key Points Blockade of inhibitory KIRs with MHC class I antigens on lymphoma cells by anti-KIR antibodies augments NK-cell spontaneous cytotoxicity. In combination with anti-CD20 mAbs, anti-KIR induces enhanced NK cell–mediated, rituximab-dependent cytotoxicity against lymphoma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/5/678/1378113/678.pdf

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