Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence-Reference-Cited by-同舟云学术

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Published:2014-01-09 Issue:2 Volume:123 Page:239-248
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sapey Elizabeth¹,Greenwood Hannah²,Walton Georgia¹,Mann Elizabeth²,Love Alexander²,Aaronson Natasha²,Insall Robert H.³,Stockley Robert A.¹,Lord Janet M.²

Affiliation:

1. School of Clinical and Experimental Medicine and

2. Medical Research Council-Arthritis Research United Kingdom Centre for Musculoskeletal Ageing Research, The Medical School, University of Birmingham, Birmingham, United Kingdom; and

3. Cancer Research-United Kingdom Beatson Institute, University of Glasgow, Glasgow, United Kingdom

Abstract

Key Points Constitutive PI3K activity is associated with less accurate neutrophil migration in healthy aged adults. This is associated with increased primary granule release and neutrophil elastase activity and may contribute to inflammation and infection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/2/239/1376655/239.pdf

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