CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia

Published:2014-01-30 Issue:5 Volume:123 Page:717-724
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

te Raa G. Doreen¹²,Pascutti Maria Fernanda¹²,García-Vallejo Juan J.³,Reinen Emilie¹,Remmerswaal Ester B. M.²⁴,ten Berge Ineke J. M.⁴,van Lier René A. W.⁵,Eldering Eric²⁶,van Oers Marinus H. J.¹⁶,Tonino Sanne H.¹⁶,Kater Arnon P.¹⁶

Affiliation:

1. Department of Hematology and

2. Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands;

3. Department of Molecular Cell Biology and Immunology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;

4. Renal Transplant Unit, Academic Medical Center, Amsterdam, The Netherlands;

5. Sanquin Blood Supply Foundation, Division of Research, Amsterdam, The Netherlands; and

6. Lymphoma and Myeloma Center Amsterdam, Amsterdam, The Netherlands

Abstract

Key PointsExpression of exhaustion markers is decreased on CMV-specific CD8+ T cells from CLL patients as compared with those from age-matched HCs. Functionality of CMV-specific CD8+ T cells in CLL with respect to cytokine production, cytotoxicity, and immune synapse formation is preserved.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/5/717/1378465/717.pdf

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5. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug.;Ramsay;J Clin Invest,2008

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