Role of RUNX1 in hematological malignancies-Reference-Cited by-同舟云学术

Role of RUNX1 in hematological malignancies

Published:2017-04-13 Issue:15 Volume:129 Page:2070-2082
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sood Raman¹^ORCID,Kamikubo Yasuhiko²,Liu Paul¹^ORCID

Affiliation:

1. Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; and

2. Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Abstract

Abstract RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. Somatic mutations and chromosomal rearrangements involving RUNX1 are frequently observed in myelodysplastic syndrome and leukemias of myeloid and lymphoid lineages, that is, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia. More recent studies suggest that the wild-type RUNX1 is required for growth and survival of certain types of leukemia cells. The purpose of this review is to discuss the current status of our understanding about the role of RUNX1 in hematological malignancies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/15/2070/1400307/blood687830.pdf

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