Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy-Reference-Cited by-同舟云学术

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy

Published:2016-04-14 Issue:15 Volume:127 Page:1912-1922
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Y. Lucy¹^ORCID,Yan Yan¹^ORCID,Webster Cody¹,Shao Lijian²,Lensing Shelly Y.³,Ni Hongyu⁴,Feng Wei²,Colorado Natalia⁵,Pathak Rupak²,Xiang Zhifu¹^ORCID,Hauer-Jensen Martin²^ORCID,Li Shaoguang⁶^ORCID,Zhou Daohong²^ORCID,Emanuel Peter D.¹^ORCID

Affiliation:

1. Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, Winthrop P. Rockefeller Cancer Institute,

2. Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, and

3. Department of Biostatistics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR;

4. Department of Pathology, University of Illinois at Chicago, Chicago, IL;

5. Division of Pediatric Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR; and

6. Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA

Abstract

Key Points Early postnatal loss of Pten protein in mice with Nf1 haploinsufficiency causes a fatal juvenile myeloproliferative neoplasm. Akt and MAPK activities are elevated in juvenile mice with Nf1 haploinsufficiency and Pten protein loss.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/15/1912/1392936/1912.pdf

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