Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood-Reference-Cited by-同舟云学术

Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood

Published:2016-01-07 Issue:1 Volume:127 Page:149-159
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tutwiler Valerie¹²,Litvinov Rustem I.²,Lozhkin Andrey P.³,Peshkova Alina D.³,Lebedeva Tatiana⁴,Ataullakhanov Fazoil I.⁵,Spiller Kara L.¹,Cines Douglas B.⁴,Weisel John W.²

Affiliation:

1. School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA;

2. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

3. Kazan Federal University, Kazan, Russia;

4. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and

5. HemaCore Ltd., Moscow, Russia

Abstract

Key PointsClot contraction has 3 phases differentially affected by platelet and fibrin mechanics, RBC compaction, and various blood components. A new dynamic quantitative clot contraction assay can reveal novel aspects of formation and evolution of hemostatic clots and thrombi.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/1/149/1391727/149.pdf

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