Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice-Reference-Cited by-同舟云学术

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Published:2015-11-19 Issue:21 Volume:126 Page:2415-2423
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liang Hai Po H.¹,Kerschen Edward J.¹,Basu Sreemanti¹,Hernandez Irene¹,Zogg Mark¹,Jia Shuang²,Hessner Martin J.²,Toso Raffaella³,Rezaie Alireza R.⁴,Fernández José A.⁵,Camire Rodney M.³,Ruf Wolfram⁶⁷,Griffin John H.⁵,Weiler Hartmut¹

Affiliation:

1. Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI;

2. Department of Pediatrics, Medical College of Wisconsin, Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI;

3. Division of Hematology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA;

4. Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, MO;

5. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA;

6. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA; and

7. Center for Thrombosis and Hemostasis, Mainz, Germany

Abstract

Key Points Factor V and protein S are required for sepsis mortality reduction and suppression of inflammatory gene expression by activated protein C. The R506Q mutation (Leiden mutation) abrogates the anti-inflammatory cofactor function of factor V for activated protein C.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/21/2415/1390122/2415.pdf

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