Carfilzomib, pomalidomide, and dexamethasone for relapsed or refractory myeloma

Author:

Shah Jatin J.1,Stadtmauer Edward A.2,Abonour Rafat3,Cohen Adam D.4,Bensinger William I.5,Gasparetto Cristina6,Kaufman Jonathan L.7,Lentzsch Suzanne8,Vogl Dan T.2,Gomes Christina L.9,Pascucci Natalia9,Smith David D.10,Orlowski Robert Z.1,Durie Brian G. M.11

Affiliation:

1. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Clinical Research Unit, University of Pennsylvania Abramson Cancer Center, Philadelphia, PA;

3. Indiana University Simon Cancer Center, Indianapolis, IN;

4. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA;

5. Clinical Research Division, Fred Hutchinson Cancer Center Research Center, Seattle, WA;

6. Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC;

7. Bone Marrow and Stem Cell Transplant Center, Winship Cancer Institute, Emory University, Atlanta, GA;

8. Division of Hematology/Oncology, Department of Medicine, Colombia University Medical Center, New York, NY;

9. Criterium, Inc–Academic Myeloma Consortium, Saratoga Springs, NY;

10. Division of Biostatistics, Department of Information Sciences, City of Hope, Duarte, CA; and

11. Cedars Sinai Samuel Oschin Cancer Center, Los Angeles, CA

Abstract

Key PointsThis is the first clinical trial to investigate CPD in multiple myeloma. Results suggest that the regimen is a well-tolerated and highly active combination for patients with relapsed/refractory multiple myeloma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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