All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo-Reference-Cited by-同舟云学术

All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo

Published:2016-06-09 Issue:23 Volume:127 Page:2867-2878
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ma Hayley S.¹^ORCID,Greenblatt Sarah M.¹,Shirley Courtney M.¹,Duffield Amy S.²,Bruner J. Kyle¹,Li Li¹,Nguyen Bao¹,Jung Eric³,Aplan Peter D.⁴,Ghiaur Gabriel¹,Jones Richard J.¹,Small Donald¹⁵

Affiliation:

1. Department of Oncology and

2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD;

3. MD Program, Penn State Hershey College of Medicine, Hershey, PA;

4. Laboratory of Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and

5. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Abstract

Key Points ATRA and FLT3 TKIs have synergistic activity against FLT3/ITD+ AML cell lines and patient samples. Combination reduces the leukemia stem cell population and improves survival in genetic and xenograft AML mouse models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/23/2867/1393803/2867.pdf

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