FXa variants advance toward a therapy for bleeding
Author:
Affiliation:
1. UNIVERSITY OF NOTTINGHAM
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/126/1/6/1345134/6.pdf
Reference5 articles.
1. Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity.;Ivanciu;Blood,2015
2. Bioengineered factor Xa as a potential new strategy for hemophilia therapy.;Camire;Expert Rev Hematol,2012
3. The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly.;Toso;J Biol Chem,2008
4. Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro.;Bunce;Blood,2011
5. A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.;Ivanciu;Nat Biotechnol,2011
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