SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells-Reference-Cited by-同舟云学术

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells

Published:2015-10-01 Issue:14 Volume:126 Page:1670-1682
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sarkar Koustav¹,Sadhukhan Sanjoy¹,Han Seong-Su¹,Vyas Yatin M.¹

Affiliation:

1. Division of Pediatric Hematology-Oncology, University of Iowa Children’s Hospital, Iowa City, IA

Abstract

Key Points SUMOylatable-WASp trans-activates and non-SUMOylatable-WASp trans-represses NF-κB response genes mediating adaptive immunity. HDAC inhibitors reverse the immunodeficient and proinflammatory phenotype caused by SUMOylation-deficient WASp in TH1 cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/14/1670/1389043/1670.pdf

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4. Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome.;Sarkar;Blood,2014

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