Integration of innate into adaptive immune responses in ZAP-70–positive chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Integration of innate into adaptive immune responses in ZAP-70–positive chronic lymphocytic leukemia

Published:2016-01-28 Issue:4 Volume:127 Page:436-448
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wagner Michaela¹,Oelsner Madlen¹,Moore Andrew²,Götte Frederik¹,Kuhn Peer-Hendrik³,Haferlach Torsten⁴,Fiegl Michael⁵,Bogner Christian¹,Baxter E. Joanna²,Peschel Christian¹,Follows George A.²,Ringshausen Ingo¹²

Affiliation:

1. 3rd Department of Medicine, Technical University Munich, Munich, Germany;

2. Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

3. Institute for Pathology and Anatomy, Institute for Advanced Study, Technical University Munich, Munich, Germany;

4. Munich Leukemia Laboratory, Munich, Germany; and

5. 3rd Department of Medicine, Ludwig Maximilian University, Munich, Germany

Abstract

Key Points Activation of innate immune receptors induces an antiapoptotic signal and proliferation in ZAP-70–positive CLL dependent on Syk activation. TLR9 activation autonomously induces BCR signaling in ZAP-70–positive CLL based on an auto/paracrine feedback loop involving immunoglobulin M.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/4/436/1394928/436.pdf

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5. ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells.;Gobessi;Blood,2007

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