MLL leukemia induction by genome editing of human CD34+ hematopoietic cells-Reference-Cited by-同舟云学术

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells

Published:2015-10-01 Issue:14 Volume:126 Page:1683-1694
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Buechele Corina¹,Breese Erin H.²,Schneidawind Dominik³,Lin Chiou-Hong¹,Jeong Johan¹,Duque-Afonso Jesus¹,Wong Stephen H. K.¹,Smith Kevin S.¹,Negrin Robert S.³,Porteus Matthew⁴,Cleary Michael L.¹

Affiliation:

1. Department of Pathology,

2. Division of Pediatric Hematology/Oncology, Department of Pediatrics,

3. Division of Blood and Marrow Transplantation, Department of Medicine, and

4. Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA

Abstract

Key Points Genome editing of primary human HSPCs generates MLL leukemias that model clinical disease features and molecular pathogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/14/1683/1389098/1683.pdf

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