Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

Author:

Karol Seth E.1,Yang Wenjian2,Van Driest Sara L.3,Chang Tamara Y.1,Kaste Sue45,Bowton Erica6,Basford Melissa6,Bastarache Lisa7,Roden Dan M.89,Denny Joshua C.79,Larsen Eric10,Winick Naomi11,Carroll William L.12,Cheng Cheng13,Pei Deqing13,Fernandez Christian A.2,Liu Chengcheng2,Smith Colton2,Loh Mignon L.14,Raetz Elizabeth A.15,Hunger Stephen P.16,Scheet Paul17,Jeha Sima1,Pui Ching-Hon1,Evans William E.2,Devidas Meenakshi18,Mattano Leonard A.19,Relling Mary V.2

Affiliation:

1. Department of Oncology and

2. Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN;

3. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN;

4. Department of Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, TN;

5. Department of Radiology, University of Tennessee, Memphis, TN;

6. Office of Research,

7. Department of Biomedical Informatics,

8. Department of Pharmacology, and

9. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN;

10. Department of Pediatrics, Maine Medical Center, Portland, ME;

11. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX;

12. Department of Pediatrics, New York University Langone Medical Center, New York, NY;

13. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN;

14. Department of Pediatrics, University of California School of Medicine, San Francisco, CA;

15. Department of Pediatrics, University of Utah, Salt Lake City, UT;

16. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

17. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX;

18. Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL; and

19. HARP Pharma Consulting, Mystic, CT

Abstract

Key Points Comprehensive study of glucocorticoid-induced osteonecrosis identifies glutamate receptor gene variants as risk factors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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