A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children

Author:

Brousseau David C.1ORCID,Scott J. Paul2,Badaki-Makun Oluwakemi3,Darbari Deepika S.4,Chumpitazi Corrie E.5,Airewele Gladstone E.6,Ellison Angela M.7,Smith-Whitley Kim8,Mahajan Prashant9,Sarnaik Sharada A.10,Casper T. Charles11,Cook Lawrence J.11,Dean J. Michael11,Leonard Julie12,Hulbert Monica L.13,Powell Elizabeth C.14,Liem Robert I.15,Hickey Robert16,Krishnamurti Lakshmanan17,Hillery Cheryl A.18,Nimmer Mark1,Panepinto Julie A.19

Affiliation:

1. Pediatric Emergency Medicine, Medical College of Wisconsin, and the Children’s Research Institute, Milwaukee, WI;

2. Pediatric Hematology and Oncology/Blood Research Institute, Medical College of Wisconsin, and the Children’s Research Institute, Milwaukee, WI;

3. Pediatric Emergency Medicine, Johns Hopkins University, Baltimore, MD;

4. Pediatric Hematology and Oncology, Children’s National Medical Center, Washington, DC;

5. Pediatric Emergency Medicine and

6. Pediatric Hematology and Oncology, Baylor College of Medicine/Texas Children’s Hospital, Houston, TX;

7. Pediatric Emergency Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;

8. Pediatric Hematology and Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA;

9. Pediatric Emergency Medicine, Wayne State University/Children’s Hospital of Michigan, Detroit, MI;

10. Pediatric Hematology and Oncology, Wayne State University/Children’s Hospital of Michigan, Detroit, MI;

11. University of Utah/Pediatric Emergency Care Applied Research Network Data Coordinating Center, Salt Lake City, UT;

12. Pediatric Emergency Medicine, Nationwide Children’s Hospital, Columbus, OH;

13. Division of Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, MO;

14. Division of Emergency Medicine and

15. Hematology, Oncology & Stem Cell Transplant, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL;

16. Pediatric Emergency Medicine, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA; and

17. Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA;

18. Pediatric Hematology and Oncology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA;

19. Pediatric Hematology and Oncology, Medical College of Wisconsin, and the Children's Research Institute, Milwaukee, WI

Abstract

Key Points Intravenous magnesium did not shorten length of stay for pain crisis in children with sickle cell anemia. Collaboration between pediatric emergency medicine and hematology allowed for successful enrollment in a sickle cell acute management trial.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference41 articles.

1. The number of people with sickle-cell disease in the United States: national and state estimates.;Brousseau;Am J Hematol,2010

2. Population estimates of sickle cell disease in the U.S.;Hassell;Am J Prev Med,2010

3. Variation in hospitalizations and hospital length of stay in children with vaso-occlusive crises in sickle cell disease.;Panepinto;Pediatr Blood Cancer,2005

4. Pain in sickle cell disease. Rates and risk factors.;Platt;N Engl J Med,1991

5. Acute care utilization and rehospitalizations for sickle cell disease.;Brousseau;JAMA,2010

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