IDH2 R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma

Author:

Wang Chao123,McKeithan Timothy W.3,Gong Qiang3,Zhang Weiwei2,Bouska Alyssa2,Rosenwald Andreas4,Gascoyne Randy D.5,Wu Xiwei6,Wang Jinhui6,Muhammad Zahid7,Jiang Bei23,Rohr Joseph23,Cannon Andrew2,Steidl Christian5,Fu Kai2,Li Yuping3,Hung Stacy5,Weisenburger Dennis D.3,Greiner Timothy C.2,Smith Lynette8,Ott German9,Rogan Eleanor G.7,Staudt Louis M.10,Vose Julie11,Iqbal Javeed2,Chan Wing C.3

Affiliation:

1. Shandong University School of Medicine, Jinan, People's Republic of China China;

2. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE;

3. Department of Pathology, City of Hope National Medical Center, Duarte, CA;

4. Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany;

5. Department of Pathology and Laboratory Medicine, BC Cancer Agency, Centre for Lymphoid Cancers and the University of British Columbia, Vancouver, BC, Canada;

6. Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, CA;

7. Department of Environmental Agricultural and Occupational Health College of Public Health and

8. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE;

9. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

10. Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and

11. Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE

Abstract

Key Points IDH2 R172 mutations define a unique subgroup with distinct TFH-like gene expression signatures in AITL. IDH2 R172 mutations can induce DNA and repressive histone hypermethylation in AITL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3