Rap1 and its effector RIAM are required for lymphocyte trafficking-Reference-Cited by-同舟云学术

Rap1 and its effector RIAM are required for lymphocyte trafficking

Published:2015-12-17 Issue:25 Volume:126 Page:2695-2703
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Su Wenjuan¹,Wynne Joseph²,Pinheiro Elaine M.³,Strazza Marianne⁴,Mor Adam⁴,Montenont Emilie⁴,Berger Jeffrey⁴,Paul David S.⁵,Bergmeier Wolfgang⁵⁶,Gertler Frank B.⁷,Philips Mark R.¹⁴^ORCID

Affiliation:

1. Perlmutter Cancer Institute and

2. Department of Medicine, University of Chicago, Chicago, IL;

3. Immune Modulatory Receptor/Oncology, Merck Research Laboratories, Boston, MA;

4. Department of Medicine, New York University School of Medicine, New York, NY;

5. McAllister Heart Institute and

6. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC; and

7. Koch Institute, Massachusetts Institute of Technology, Cambridge, MA

Abstract

Key Points Rap1 and its effector RIAM are required for integrin-mediated T-cell adhesion and homing to lymph nodes, but not for T-cell development. RIAM regulates the activation of lymphocyte function-associated antigen 1 and very late antigen 4 on lymphocytes, but not αIIbβ3 on platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/25/2695/1390342/2695.pdf

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5. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.;Lafuente;Dev Cell,2004

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