Efficacy of transfusion with granulocytes from G-CSF/dexamethasone–treated donors in neutropenic patients with infection

Author:

Price Thomas H.12,Boeckh Michael13,Harrison Ryan W.4,McCullough Jeffrey5,Ness Paul M.6,Strauss Ronald G.7,Nichols W. Garrett38,Hamza Taye H.4,Cushing Melissa M.9,King Karen E.6,Young Jo-Anne H.5,Williams Eliot10,McFarland Janice11,Holter Chakrabarty Jennifer12,Sloan Steven R.13,Friedman David14,Parekh Samir15,Sachais Bruce S.1617,Kiss Joseph E.1819,Assmann Susan F.4

Affiliation:

1. Department of Medicine, University of Washington, Seattle, WA;

2. Bloodworks Northwest, Seattle, WA;

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

4. New England Research Institutes, Watertown, MA;

5. Department of Laboratory Medicine and Pathology, Department of Medicine, University of Minnesota, Minneapolis, MN;

6. Department of Pathology, Division of Transfusion Medicine, Johns Hopkins Hospital, Baltimore, MD;

7. Department of Pathology, University of Iowa Hospital, Iowa City, IA;

8. Chimerix Inc, Durham, NC;

9. Department of Pathology, Weill Cornell Medical College, New York, NY;

10. Department of Medicine, University of Wisconsin, Madison, WI;

11. BloodCenter of Wisconsin, Milwaukee, WI;

12. Department of Medicine, University of Oklahoma, Oklahoma City, OK;

13. Department of Laboratory Medicine, Boston Children’s Hospital, Boston, MA;

14. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

15. Division of Hematology-Oncology, Montefiore Medical Center, Bronx, NY;

16. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;

17. New York Blood Center, New York, NY;

18. Division of Medical Oncology and Hematology, University of Pittsburgh, Pittsburgh, PA; and

19. Institute for Transfusion Medicine, Pittsburgh, PA

Abstract

Key Points Overall, no benefit of granulocyte transfusion therapy was observed, but the power of the study was reduced due to low accrual. Post hoc secondary analysis suggested that patients receiving higher doses tended to have better outcomes than those receiving lower ones.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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