Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI

Author:

Copelan Edward A.1,Hamilton Betty K.2,Avalos Belinda1,Ahn Kwang Woo3,Bolwell Brian J.2,Zhu Xiaochun3,Aljurf Mahmoud4,van Besien Koen5,Bredeson Christopher6,Cahn Jean-Yves7,Costa Luciano J.8,de Lima Marcos9,Gale Robert Peter10,Hale Gregory A.11,Halter Joerg12,Hamadani Mehdi13,Inamoto Yoshihiro14,Kamble Rammurti T.15,Litzow Mark R.16,Loren Alison W.17,Marks David I.18,Olavarria Eduardo19,Roy Vivek20,Sabloff Mitchell6,Savani Bipin N.21,Seftel Matthew22,Schouten Harry C.23,Ustun Celalettin24,Waller Edmund K.25,Weisdorf Daniel J.24,Wirk Baldeep26,Horowitz Mary M.3,Arora Mukta24,Szer Jeff27,Cortes Jorge28,Kalaycio Matt E.2,Maziarz Richard T.29,Saber Wael3

Affiliation:

1. Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;

2. Cleveland Clinic Foundation, Cleveland, OH;

3. Center for International Blood and Marrow Transplant Research, Milwaukee, WI;

4. King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia;

5. Weill Cornell Medical College, New York, NY;

6. Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;

7. Department of Hematology, University Hospital, Grenoble, France;

8. Medical University of South Carolina, Charleston, SC;

9. University Hospitals Case Medical Center, Cleveland, OH;

10. Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, United Kingdom;

11. All Children’s Hospital, St. Petersburg, FL;

12. University Hospital Basel, Basel, Switzerland;

13. West Virginia University Hospitals, Morgantown, WV;

14. Fred Hutchinson Cancer Research Center, Seattle, WA;

15. Baylor College of Medicine Center for Cell and Gene Therapy, Houston, TX;

16. Mayo Clinic Rochester, Rochester, MN;

17. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

18. Bristol Children’s Hospital, Bristol, United Kingdom;

19. Catherine Lewis Center, Pamplona, Spain;

20. Mayo Clinic, Jacksonville, FL;

21. Vanderbilt University Medical Center, Brentwood, TN;

22. Cancer Care Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada;

23. Academische Ziekenhuis Maastricht, Maastricht, The Netherlands;

24. University of Minnesota Medical Center, Fairview, Minneapolis, MN;

25. Emory University Hospital, Atlanta, GA;

26. Shands HealthCare and University of Florida, Gainesville, FL;

27. Royal Melbourne Hospital City Campus, Victoria, Australia;

28. MD Anderson Cancer Center, Houston, TX; and

29. Oregon Health and Science University, Portland, OR

Abstract

Key Points In combination with cyclophosphamide, intravenous busulfan is associated with better leukemia-free and overall survival in AML than TBI.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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