Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1-Reference-Cited by-同舟云学术

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1

Published:2014-01-23 Issue:4 Volume:123 Page:509-519
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

de Laval Bérengère¹²³,Pawlikowska Patrycja¹²³,Barbieri Daniela¹²³,Besnard-Guerin Corinne¹²³,Cico Alba¹²³,Kumar Rajiv⁴,Gaudry Murielle¹²³,Baud Véronique¹²³,Porteu Françoise¹²³

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Paris, France;

2. Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, Institut Cochin, Paris, France;

3. Université Paris Descartes, Sorbonne Paris Cité, Paris, France; and

4. Departments of Internal Medicine, Biochemistry, and Molecular Biology, Mayo Clinic, Rochester, MN

Abstract

Key Points TPO specifically activates Erk and NF-κB pathways in hematopoietic stem and progenitor cells. Erk and NF-κB cooperate to trigger their common target, Iex-1, and DNA-PK-dependent NHEJ activation in HSPCs upon irradiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/509/1378373/509.pdf

Reference60 articles.

1. Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure.;Simonnet;Stem Cells,2009

2. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells.;Wang;Free Radic Biol Med,2010

3. Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.;Fleenor;Cell Cycle,2010

4. Mechanisms of DNA double strand break repair and chromosome aberration formation.;Iliakis;Cytogenet Genome Res,2004

5. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.;Ferguson;Proc Natl Acad Sci USA,2000

Cited by 53 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DNA damage repair in megakaryopoiesis: molecular and clinical aspects;Expert Review of Hematology;2024-08-13

2. Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome;Stem Cell Research & Therapy;2024-04-29

3. Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome;2024-02-19

4. The DNA damage and regulatory strategy in hematopoietic stem cells after irradiation exposure: Progress and challenges;Radiation Medicine and Protection;2023-12

5. PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury;Scientific Reports;2023-09-14