The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)

Author:

Hartmann Sylvia1,Eichenauer Dennis A.23,Plütschow Annette23,Mottok Anja4,Bob Roshanak5,Koch Karoline6,Bernd Heinz-Wolfram7,Cogliatti Sergio8,Hummel Michael9,Feller Alfred C.7,Ott German10,Möller Peter11,Rosenwald Andreas4,Stein Harald5,Hansmann Martin-Leo1,Engert Andreas23,Klapper Wolfram6

Affiliation:

1. Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany;

2. First Department of Internal Medicine and

3. German Hodgkin Study Group, University Hospital of Cologne, Germany;

4. Institute of Pathology, University of Würzburg and Comprehensive Cancer Center (CCC) Mainfranken, Germany;

5. Pathodiagnostic Berlin, Berlin Reference Center for Lymphoma and Hematopathology, Berlin, Germany;

6. Institute of Pathology, Haematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany;

7. Institute of Pathology, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany;

8. Institute of Pathology, Kantonsspital St. Gallen, Switzerland;

9. Institute of Pathology, Charité University Hospital, Berlin, Germany;

10. Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; and

11. Institute of Pathology, University Hospital Ulm, Germany

Abstract

Key PointsHistopathologic variants of nodular lymphocyte–predominant Hodgkin lymphoma are associated with advanced stage and increased relapse rate. A prognostic score combining histopathologic and clinical features can allocate patients to 3 defined risk groups.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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