Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo-Reference-Cited by-同舟云学术

Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo

Published:2014-03-06 Issue:10 Volume:123 Page:1564-1573
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Poli Maura¹,Asperti Michela¹,Naggi Annamaria²,Campostrini Natascia³,Girelli Domenico³,Corbella Michela³,Benzi Marina²,Besson-Fournier Celine⁴,Coppin Helene⁴,Maccarinelli Federica¹,Finazzi Dario¹,Arosio Paolo¹

Affiliation:

1. Molecular Biology laboratory, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy;

2. G. Ronzoni Institute for Chemical and Biochemical Research, Milano, Italy;

3. Department of Medicine, University of Verona, Verona, Italy; and

4. Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse and Centre National de la Recherche Scientifique, U5282, Toulouse, France

Abstract

Key Points Chemically modified nonanticoagulant heparins are strong inhibitors of hepcidin expression in normal and Bmp6−/− mice. These heparins abolish hepcidin induction caused by LPS, a model of inflammation, and are candidates for treatment of inflammatory anemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/10/1564/1374173/1564.pdf

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