Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity-Reference-Cited by-同舟云学术

Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

Published:2014-01-02 Issue:1 Volume:123 Page:15-25
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hossain Dewan Md Sakib¹,Dos Santos Cedric²,Zhang Qifang¹,Kozlowska Anna¹³,Liu Hongjun²,Gao Chan¹,Moreira Dayson¹,Swiderski Piotr⁴,Jozwiak Agnieszka⁴,Kline Justin⁵,Forman Stephen²,Bhatia Ravi²,Kuo Ya-Huei²,Kortylewski Marcin¹

Affiliation:

1. Departments of Cancer Immunotherapeutics and Tumor Immunology and

2. Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute at City of Hope, Duarte, CA;

3. Medical Biotechnology, University of Medical Sciences, Poznan, Poland;

4. DNA/RNA Synthesis Core Facility, Beckman Research Institute at City of Hope, Duarte, CA; and

5. Department of Medicine, University of Chicago, Chicago, IL

Abstract

Key Points Blocking STAT3 in acute myeloid leukemia cells stimulates their TLR9-induced immunogenicity and antigen-specific activation of CD8+ T cells. Systemic delivery of CpG-Stat3 siRNA generates potent adaptive immune responses eradicating disseminated acute myeloid leukemia in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/1/15/1373558/15.pdf

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