Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

Author:

Krevvata Maria1,Silva Barbara C.1,Manavalan John S.1,Galan-Diez Marta1,Kode Aruna1,Matthews Brya Grace2,Park David3,Zhang Chiyuan A.1,Galili Naomi4,Nickolas Thomas L.5,Dempster David W.6,Dougall William7,Teruya-Feldstein Julie3,Economides Aris N.8,Kalajzic Ivo2,Raza Azra4,Berman Ellin9,Mukherjee Siddhartha10,Bhagat Govind11,Kousteni Stavroula1

Affiliation:

1. Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY;

2. Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT;

3. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY;

4. Myelodysplastic Syndromes Center and

5. Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, NY;

6. Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York, NY;

7. Amgen Inc., Seattle, WA;

8. Bone and Cartilage Biology Group, Genome Engineering Technologies Group, Regeneron Pharmaceuticals Inc., Tarrytown, NY;

9. Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY;

10. Department of Medicine, Division of Hematology and Oncology, and

11. Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY

Abstract

Key Points Acute myeloid leukemia decreases osteoblast numbers in humans and mice. Reinstatement of osteoblast number and function in leukemic mice by a pharmacologic approach reduces tumor burden in all sites and prolongs survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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