Pharmacologic increase in HIF1α enhances hematopoietic stem and progenitor homing and engraftment-Reference-Cited by-同舟云学术

Pharmacologic increase in HIF1α enhances hematopoietic stem and progenitor homing and engraftment

Published:2014-01-09 Issue:2 Volume:123 Page:203-207
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Speth Jennifer M.¹,Hoggatt Jonathan¹²,Singh Pratibha¹,Pelus Louis M.¹

Affiliation:

1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN; and

2. Department of Stem Cell and Regenerative Biology, Harvard University/Harvard Stem Cell Institute, Cambridge, MA

Abstract

Key Points dmPGE2 stabilizes the transcription factor HIF1α in stem and progenitor cells. Pharmacologic stabilization of HIF1α increases CXCR4 and enhances stem and progenitor homing and engraftment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/2/203/1377138/203.pdf

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