Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring

Author:

Li Ye-Xiong1,Fang Hui1,Liu Qing-Feng1,Lu Jiade2,Qi Shu-Nan1,Wang Hua1,Jin Jing1,Wang Wei-Hu1,Liu Yue-Ping1,Song Yong-Wen1,Wang Shu-Lian1,Liu Xin-Fan1,Feng Xiao-Li3,Yu Zi-Hao1

Affiliation:

1. Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People's Republic of China;

2. Department of Radiation Oncology, National University Hospital of Singapore, Singapore; and

3. Department of Pathology, Cancer Hospital, CAMS and PUMC, Beijing, People's Republic of China

Abstract

Abstract The clinical characteristics and prognosis remain unclear for nasal-type NK/T-cell lymphoma of Waldeyer ring (WR-NKTL). The aim of this study is to determine the clinical features and outcome. Ninety-one patients with WR-NKTL were reviewed. According to the Ann Arbor system, 15, 56, 12, and 8 patients had stage I, II, III, and IV. Of patients with stage I and II, 54 received combined chemotherapy and radiotherapy (CMT), 13 received radiotherapy alone, and 4 patients received chemotherapy alone. All 20 patients with stage III/IV received primary chemotherapy. The disease is characterized by predominance in young males, good performance, a propensity for nodal involvement, frequent stage II through IV diseases, low frequency of elevated LDH, low-risk international prognostic index (IPI), high sensitivity to radiotherapy, and intermediate sensitivity to chemotherapy. The 5-year overall survival and progression-free survival for all patients were 65% and 51%, respectively. The age, B symptoms, stage, and IPI were important prognostic factors. CMT tended to improve the survival compared with radiotherapy alone for patients with stage I and II diseases. Both nodal involvement and distant extranodal dissemination were the primary failure patterns. WR-NKTL appears to have distinct clinical characteristics and favorable outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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