Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity

Author:

Mitchell Joanne L.1ORCID,Lionikiene Ausra S.1,Georgiev Georgi1,Klemmer Anja1,Brain Chelsea1,Kim Paul Y.2,Mutch Nicola J.1ORCID

Affiliation:

1. Institute of Medical Sciences, School of Medicine, Medical Sciences, and Nutrition, University of Aberdeen, Aberdeen, United Kingdom; and

2. Thrombosis and Atherosclerosis Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada

Abstract

Key PointsPolyP significantly augments the plasminogen activator capacity of FXIIa. Platelet-bound fibrin acts as a reservoir for plasminogen, FXII(a), and polyP.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference65 articles.

1. Accelerating effect of zinc ions on the surface-mediated activation of factor XII and prekallikrein;Shimada;J Biochem,1987

2. Acceleration of surface-dependent autocatalytic activation of blood coagulation factor XII by divalent metal ions;Shore;Biochemistry,1987

3. Surface-independent acceleration of factor XII activation by zinc ions. II. Direct binding and fluorescence studies;Bernardo;J Biol Chem,1993

4. Surface-independent acceleration of factor XII activation by zinc ions. I. Kinetic characterization of the metal ion rate enhancement;Bernardo;J Biol Chem,1993

5. The inositol-phospholipid-accelerated activation of prekallikrein by activated factor XII at physiological ionic strength requires zinc ions and high-Mr kininogen;Schousboe;Eur J Biochem,1990

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