FVIII-binding IgG modulates FVIII half-life in patients with severe and moderate hemophilia A without inhibitors-Reference-Cited by-同舟云学术

FVIII-binding IgG modulates FVIII half-life in patients with severe and moderate hemophilia A without inhibitors

Published:2016-07-14 Issue:2 Volume:128 Page:293-296
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hofbauer Christoph J.¹,Kepa Sylvia²,Schemper Michael³,Quehenberger Peter⁴,Reitter-Pfoertner Sylvia²,Mannhalter Christine⁴,Reipert Birgit M.¹,Pabinger Ingrid²

Affiliation:

1. Department of Immunology, Research & Innovation, Baxalta, Vienna, Austria;

2. Clinical Division of Haematology and Haemostaseology, Department of Medicine I,

3. Center for Medical Statistics, Informatics and Intelligent Systems, and

4. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

Abstract

Key Points FVIII-specific IgG antibodies modulate FVIII half-life in patients with hemophilia A, independent of VWF antigen levels and age. Screening for FVIII-specific IgG may be beneficial in tailoring FVIII prophylactic regimens for hemophilia A patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/2/293/1397524/293.pdf

Reference13 articles.

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3. Are low-density lipoprotein receptor-related protein 1 or non-neutralizing antibodies predictors of FVIII in vivo recovery in haemophilia A patients?;Clere;Haemophilia,2014

4. The half-life of infused factor VIII is shorter in hemophiliac patients with blood group O than in those with blood group A.;Vlot;Thromb Haemost,2000

5. Inter-individual variation in half-life of infused recombinant factor VIII is related to pre-infusion von Willebrand factor antigen levels.;Fijnvandraat;Br J Haematol,1995

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