Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD-Reference-Cited by-同舟云学术

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Published:2016-02-04 Issue:5 Volume:127 Page:646-657
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Alho Ana C.¹²³,Kim Haesook T.⁴⁵⁶,Chammas Marie J.¹,Reynolds Carol G.¹,Matos Tiago R.¹²,Forcade Edouard¹²,Whangbo Jennifer¹²,Nikiforow Sarah¹²,Cutler Corey S.¹²,Koreth John¹²,Ho Vincent T.¹²,Armand Philippe¹²,Antin Joseph H.¹²,Alyea Edwin P.¹²,Lacerda Joao F.³,Soiffer Robert J.¹²,Ritz Jerome¹²⁵

Affiliation:

1. Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA;

2. Harvard Medical School, Boston, MA;

3. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;

4. Department of Biostatistics and Computational Biology, and

5. Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA; and

6. Harvard Chan School of Public Health, Boston, MA

Abstract

Key Points Homeostatic recovery after allogeneic HSCT favors the production, expansion, and survival of effector T cells over CD4Tregs. Unbalanced reconstitution of regulatory and effector T-cell subsets contributes to the development of chronic graft-versus-host disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/5/646/1395162/646.pdf

Reference47 articles.

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3. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans.;Storek;Semin Immunopathol,2008

4. Immune cell subset counts associated with graft-versus-host disease.;Podgorny;Biol Blood Marrow Transplant,2014

5. Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation.;Mirmonsef;Blood,2008

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