Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia

Author:

Karol Seth E.1,Mattano Leonard A.2,Yang Wenjian3,Maloney Kelly W.4,Smith Colton3,Liu ChengCheng3,Ramsey Laura B.3,Fernandez Christian A.3,Chang Tamara Y.1,Neale Geoffrey5,Cheng Cheng6,Mardis Elaine7,Fulton Robert7,Scheet Paul8,San Lucas F. Anthony8,Larsen Eric C.9,Loh Mignon L.10,Raetz Elizabeth A.11,Hunger Stephen P.12,Devidas Meenakshi13,Relling Mary V.3

Affiliation:

1. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

2. HARP Pharma Consulting, Mystic, CT;

3. Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN;

4. Center for Cancer and Blood Disorders, Children’s Hospital Colorado, Denver, CO;

5. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN;

6. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN;

7. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO;

8. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX;

9. Department of Pediatrics, Maine Medical Center, Portland, ME;

10. Department of Pediatrics, University of California School of Medicine, San Francisco, CA;

11. Department of Pediatrics, University of Utah, Salt Lake City, UT;

12. Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; and

13. Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL

Abstract

Key Points Variants in genes important for mesenchymal stem cell differentiation influence the risk of osteonecrosis in children with ALL under 10 years old. Variants in genes in the glutamate signaling pathway influence osteonecrosis in children with ALL regardless of age.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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