Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice-Reference-Cited by-同舟云学术

Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice

Published:2016-05-26 Issue:21 Volume:127 Page:2630-2637
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Heestermans Marco¹²,Salloum-Asfar Salam¹²,Salvatori Daniela³,Laghmani El Houari⁴,Luken Brenda M.⁵,Zeerleder Sacha S.⁵,Spronk Henri M. H.⁶,Korporaal Suzanne J.⁷,Wagenaar Gerry T. M.⁴,Reitsma Pieter H.¹²,van Vlijmen Bart J. M.¹²

Affiliation:

1. Einthoven Laboratory for Experimental Vascular Medicine,

2. Department of Internal Medicine, Division of Thrombosis and Hemostasis,

3. Central Laboratory Animal Facility, and

4. Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands;

5. Department of Immunopathology, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands;

6. Department of Internal Medicine and Biochemistry, Maastricht University, Maastricht, The Netherlands; and

7. Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

Key Points Platelets, neutrophils, and coagulation factor XII are implicated as important players in experimental venous thrombosis pathophysiology. We demonstrate that platelets, but not neutrophils, are critical in spontaneous venous thrombosis, whereas low factor XII aggravates thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/21/2630/1394083/2630.pdf

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