Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

Author:

Hergott Christopher B.1,Roche Aoife M.1,Tamashiro Edwin12,Clarke Thomas B.3,Bailey Aubrey G.1,Laughlin Alice1,Bushman Frederic D.1,Weiser Jeffrey N.145

Affiliation:

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

2. Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto School of Medicine, University of São Paulo, São Paulo, Brazil;

3. Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom;

4. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and

5. Department of Microbiology, New York University School of Medicine, New York, NY

Abstract

Key Points The intestinal microbiota regulates the steady-state survival and turnover kinetics of circulating neutrophils and inflammatory monocytes. The cytoplasmic peptido-glycan sensor Nod1 relays microbial signals into IL-17A–dependent stimulation of myeloid cell persistence.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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