MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells-Reference-Cited by-同舟云学术

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

Published:2016-11-10 Issue:19 Volume:128 Page:2307-2318
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sheikh Bilal N.¹²,Yang Yuqing¹²,Schreuder Jaring¹²,Nilsson Susan K.³⁴,Bilardi Rebecca¹²,Carotta Sebastian¹²,McRae Helen M.¹²,Metcalf Donald¹,Voss Anne K.¹²,Thomas Tim¹²

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia;

2. Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia;

3. Manufacturing Commonwealth Scientific and Industrial Research Organisation, Clayton, VIC, Australia; and

4. Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia

Abstract

Key Points MOZ deletion in adult mice leads to a rapid loss of cells with HSC cell surface immuno-phenotype and transplantation ability. Absence of classically defined HSCs for an extended period does not substantially affect steady-state hematopoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/19/2307/1396417/2307.pdf

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