Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells-Reference-Cited by-同舟云学术

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells

Published:2016-08-25 Issue:8 Volume:128 Page:1063-1075
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dhahri Douaa¹²,Sato-Kusubata Kaori¹²,Ohki-Koizumi Makiko¹²,Nishida Chiemi¹³²,Tashiro Yoshihiko³²,Munakata Shinya³²,Shimazu Hiroshi³²,Salama Yousef¹²,Eiamboonsert Salita¹²,Nakauchi Hiromitsu⁴²,Hattori Koichi¹³⁴⁵²,Heissig Beate¹⁴⁵²

Affiliation:

1. Division of Stem Cell Dynamics,

2. Atopy (Allergy) Center, Juntendo University School of Medicine, Tokyo, Japan

3. Division of Stem Cell Regulation, and

4. Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science at the University of Tokyo, Tokyo, Japan; and

5. Center for Genome and Regenerative Medicine and

Abstract

Key Points tPA expands mesenchymal stromal cells (MSCs) in the bone marrow by a cytokine (KitL and PDGF-BB) crosstalk with endothelial cells. Pharmacologic inhibition of receptor tyrosine kinases (c-Kit and PDGFRα) impairs tPA-mediated MSC proliferation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/8/1063/1465267/1063.pdf

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